to approximately 60% of the maximum. For example, in 2 RCTs, the dose of 150 minutes of moderate aerobic exercise per week was sufficient to be cognitively protective31 and associated with increased hippocampal volume plus improved spatial memory.15 Such moderate intensity is a practical exercise target, recognizing that greater exercise intensity might not be tolerated and lead to greater numbers of study dropouts or nonadherence, at least initially.