The SADAS-cog, Qmci, Clinical Dementia Rating (CDR) scale, and the LawtoneBrady activities of daily
living (ADL) scale were assessed at multiple time points, over 1 year in a multicenter randomized clinical trial of 406 patients with mild to
moderate Alzheimer’s dementia. Correlations were estimated using regression at each time point, all time points, and mean values across
time. Responsiveness was assessed using the standardized response mean (SRM).