The results of this study indicate that the neglect, ADL, and balance of UN patients with right hemispheric stroke can be improved through the participation of primary caregivers in VR; however, no significant effects were observed in the number of falls. VR is feasible for clinical application. Nearly all hospitalized stroke patients in Taiwan have informal caregivers to assist in their ADL. These informal caregivers could guide and supervise patients in VR after receiving brief (20-minute to 40-minute) training from RNs.