4. Conclusion
The use of MIPs has been proposed for the extraction of traces
of NSAID compounds as ketoprofen, naproxen, ibuprofen and
diclofenac in water and urine samples and their determination by
liquid chromatography with different detectors. The performance
of DAD and MS–MS detectors was evaluated, with LOD values for
the studied compounds from 0.3 to 0.4 mg L−1 and from 0.3 to
0.8 g L−1, respectively. The proposed MIP extraction was applied
for urine monitoring of NSAID residues in prescribed individuals,
being an effective tool to improve selectivity of LC-DAD determinations.
A brief study of NSAID excretion in human urine was carried
out in prescribed individuals identifying the maximum excretion
times and quantifying the drug concentration.
Ta