Results of laboratory investigations on the day the diflunisal was stopped
were: haemoglobin 15-4 g/dl; white cell count 6 x 109/1 (6000/mm3), normal
differential; erythrocyte sedimentation rate (ESR) 10 mm in first hour;
serum urea and electrolytes normal; total bilirubin 57 jmol/l (3-3 mg/100
ml); alkaline phosphatase 780 IU/l (normal 120-300 IU/1); and serum AST
120 IU/l (normal less than 40 IU/1). Urine contained a normal amount of
urobilinogen; bile salts and bilirubin were detected; a midstream specimen
was sterile and contained no excess of cells; and hepatitis B antigen was not
detected in the serum. Three days later the serum bilirubin was 71 ,umol/l
(4-2 mg/100 ml), alkaline phosphatase 800 IU/1, and AST 105 IU/1. Four
days later the bilirubin was 55 ,tmol/l (3-2 mg/100 ml), and 12 days after
the diflunisal was stopped an oral cholecystogram showed a normal functioning
gall bladder with no evidence of calculi. A chest radiograph was
normal. Neither antimitochondrial antibodies nor smooth-muscle antibodies
were detected.
Results of laboratory investigations on the day the diflunisal was stoppedwere: haemoglobin 15-4 g/dl; white cell count 6 x 109/1 (6000/mm3), normaldifferential; erythrocyte sedimentation rate (ESR) 10 mm in first hour;serum urea and electrolytes normal; total bilirubin 57 jmol/l (3-3 mg/100ml); alkaline phosphatase 780 IU/l (normal 120-300 IU/1); and serum AST120 IU/l (normal less than 40 IU/1). Urine contained a normal amount ofurobilinogen; bile salts and bilirubin were detected; a midstream specimenwas sterile and contained no excess of cells; and hepatitis B antigen was notdetected in the serum. Three days later the serum bilirubin was 71 ,umol/l(4-2 mg/100 ml), alkaline phosphatase 800 IU/1, and AST 105 IU/1. Fourdays later the bilirubin was 55 ,tmol/l (3-2 mg/100 ml), and 12 days afterthe diflunisal was stopped an oral cholecystogram showed a normal functioninggall bladder with no evidence of calculi. A chest radiograph wasnormal. Neither antimitochondrial antibodies nor smooth-muscle antibodieswere detected.
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