Reprogramming energy metabolism has been identified as an emerging hallmark in cancer cells. To sustain uncontrolled proliferation, cancer cells make adjustments to their energy production by reprogramming their glucose metabolism
Upregulating glucose transporters such as glucose transporter 1(GLUT1)
Depending on alternate metabolic pathways Although limiting energy production to the glycolysis phase decreases the amount of adenosine triphosphate (ATP) produced, it also allows cancer cells to divert glycolic intermediates to various pathways, including those required to assemble new cells.Molecular cancer research also reveals a number of activating mutations in enzymes found in glioblastoma that confer an advantage to altering tumor cell energetics.