This growing problem was characterized by the infectious diseases caused by multidrug-resistant Gram-negative bacteria that challenge the public health policies worldwide at the point of being known as the ESKAPE pathogens [Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa(P. aeruginosa) and Enterobacter spp.]. This term represents their escape from the effects of the antibacterial agents or the nonexistence of newer and more effective antibiotics