But none of themshowed any response even after four weeks of therapy.After excluding secondary causes of nephroticsyndrome (complement level, anti nuclear antibody,HBsAg and HCV), renal biopsy was done in all threepatients and their histopathological findings werecompatible with Type-1 MembranoproliferativeGlomerulonephritis. As secondary causes wereexcluded, our histopathological diagnosis was MPGNType-1 variant of INS. After taking permission fromethical board in BSMMU and proper counseling of theparents, these patients were treated with injectionMethyl prednisolone alternate day for 6 pulses. Whenthey were in remission, oral cyclophosphamide (12weeks), and alternate day oral prednisolone (1.5 mg/kg), was administered that was gradually tapered over6 month.
But none of them<br>showed any response even after four weeks of therapy.<br>After excluding secondary causes of nephrotic<br>syndrome (complement level, anti nuclear antibody,<br>HBsAg and HCV), renal biopsy was done in all three<br>patients and their histopathological findings were<br>compatible with Type-1 Membranoproliferative<br>Glomerulonephritis. As secondary causes were<br>excluded, our histopathological diagnosis was MPGN<br>Type-1 variant of INS. After taking permission from<br>ethical board in BSMMU and proper counseling of the<br>parents, these patients were treated with injection<br>Methyl prednisolone alternate day for 6 pulses. When<br>they were in remission, oral cyclophosphamide (12<br>สัปดาห์ที่ผ่านมา) และวันอื่น prednisolone ในช่องปาก (1.5 มก. / <br>กก.) เป็นยาที่ค่อย ๆ เรียวกว่า<br>6 เดือน
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