Pulsatilla is highly toxic, and produces cardiogenic toxins and oxytoxins which slow the heart in humans. Excess use can lead to diarrhea, vomiting and convulsions,[5] hypotension and coma.[6] It has been used as a medicine by Native Americans for centuries. Blackfoot Indians used it to induce abortions and childbirth.[5] Pulsatilla should not be taken during pregnancy nor during lactation.[7]
Extracts of Pulsatilla have been used to treat reproductive problems such as premenstrual syndrome and epididymitis.[7] Additional applications of plant extracts include uses as a sedative and for treating coughs.[7] It is also used as an initial ingredient in homeopathic remedies.[7]