Their paper does not discuss points III or IV. They perform a large number (318) of simulations with different control structures, controllers (P or PI), and tunings on a simple process consisting of a reactor, separator and recycle of unreacted reactant. The configurations are ranked based on integrated absolute error of the product composition for steps in the disturbance. From these simulation they propose some guidelines for selecting the throughput manipulator and inventory controls. (1) Prefer internal flows as throughput manipulator. (2) the throughput manipulator and inventory controls should be self-consistent (self-consistency is fulfilled when a change in the throughput propagates through the process by “itself” and does not depend on composition controllers). They apply their ideas on the Tennessee Eastman problem (Price et al., 1994).