risk of developing end-stage kidney disease with a need for renal replacement therapy. Perhaps the greatest challenge is the risk of recurrence of the disease post-transplant, which is 30-50% for the first graft and higher for subsequent one [6]. The nature of the condition and the proportion of familial forms of NS have led to much work on the genetics of NS, with a resultant expansion in the knowledge of genes involved.
This article reviews the pathogenesis, clinical presentation, diagnosis, complications, management and long term outcome of children with steroid sensitive NS.