Investigator’s evaluation In the investigator’s assessment of skin whitening, 3.3% of the subjects received a score of 2 at Week 10 for placebo sites (Table 3). In contrast, a skin-whitening score of 2 was received by 13.3% (Week 6), 36.7% (Week 8), and 66.7% (Week 10) of subjects at GSSG sites. In the investigator’s assessment of wrinkle reduction, none of the sites that received placebo lotion received a score of 2. However, a wrinkle-reduction score of 2 was received by 3.3% (Week 4), 10.0% (Week 6), 20.0% (Week 8), and 33.3% (Week 10) of subjects at GSSG sites. Skin-smoothing effi- cacy did not differ between the placebo and GSSG sites in the investigator’s assessment (data not shown).