. Marinara pizza: Unfortunately, the ultimate late night indulgence is a recipe for disaster in every way: Alcohol loosens up the muscles that keep your food and digestive juices down, and the acidic tomatoes in marinara sauce (and salsa and hot sauce) can provoke GERD, acid reflux, and heartburn, says George Koob, Ph.D., director of the National Institute on Alcohol Abuse and Alcoholism for the National Institutes of Health. They're especially bad when you eat them late at night right before you lie down, when gravity stops helping you keep your food down. Bring on the white pizza — as long as it's not too greasy, it's a better bet. (Too much fat can aggravate your stomach too.) Just blot the oil with a napkin if your slice runneth over.