Incidence and Prognostic Importance of Acute Renal Failure After Percutaneous Coronary Intervention.
Methods and Results— With a retrospective analysis of the Mayo Clinic PCI registry, we determined the incidence of, risk factors for, and prognostic implications of ARF (defined as an increase in serum creatinine [Cr] >0.5 mg/dL from baseline) after PCI. Of 7586 patients, 254 (3.3%) experienced ARF. Among patients with baseline Cr <2.0, the risk of ARF was higher among diabetic than nondiabetic patients, whereas among those with a baseline Cr >2.0, all had a significant risk of ARF. In multivariate analysis, ARF was associated with baseline serum Cr, acute myocardial infarction, shock, and volume of contrast medium administered. Twenty-two percent of patients with ARF died during the index hospitalization compared with only 1.4% of patients without ARF (P<0.0001). After adjustment, ARF remained strongly associated with death. Among hospital survivors with ARF, 1- and 5-year estimated mortality rates were 12.1% and 44.6%, respectively, much greater than the 3.7% and 14.5% mortality rates in patients without ARF (P<0.0001).
Conclusions
We conclude that although the overall incidence of ARF after PCI is low, (1) patients with baseline elevation of serum Cr concentration are at high risk of ARF after PCI, (2) patients who experience ARF after PCI are at very high risk of in hospital death, and (3) patients with worsening renal function are at very high risk of death or myocardial infarction in follow-up.
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