Search methods for identification of studies
Electronic searches
In this updated review, we searched the following bibliographic databases: the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 2); Ovid MEDLINE (1966 to February 2016 ); Ovid EMBASE (1988 to February 2016 ); OVID
Evidence-Based Medicine Reviews (includes Cochrane Database of Systematic Reviews, CENTRAL, ACP Journal Club, and
Database of Abstracts of Reviews of Effectiveness (DARE)); ISI Web of Science - ScienceCitation IndexExpanded (1965 to February 2016); WebSPIRS Biological Abstracts (1969 to February 2016); and WebSPIRS CAB Abstracts (1972 to February 2016). We also searched the following trial registries: ClinicalTrials.gov; CenterWatch Clinical Trials Listing Service; Current Controlled Trials; GlaxoSmithKline Clinical Trial Register; National Clinical Trials Registry and the National Research Register (all found at www.ualberta.ca/ARCHE/litsearch.html#trials)