Laryngopharyngeal reflux (LPR) is a pervasive disorder that may cause hoarseness, throat
clearing, and other symptoms. These symptoms are particularly problematic in professional voice users. Proton pump
inhibitors (PPIs) are the mainstay of current medical management for LPR but may be insufficient in managing some
patients’ symptoms. Laparoscopic Nissen fundoplication (LNF) is well established for treatment of gastroesophageal
reflux disease with a high success rate, but its role in the treatment of LPR remains uncertain. This study was designed
to investigate the effectiveness of anti-reflux surgery in managing disease refractory to medical reflux therapy (twice of
more per day PPIs).