Most patients will recover without therapy, however, itraconazole should be considered if the patient’s condition has not improved after 1 month
In patients with a moderate to severe case of acute pulmonary histoplasmosis and PDH, a lipid emulsion of amphotericin B with glucocorticoids is given for 1- 2 weeks, then intraconazole for 12 weeks
Be sure to monitor renal and hepatic function for medication side effects