Instead, a cellular immune response was observed.
Incubation of spleen cells with SC3 resulted in a 1.5- to
2.5-fold increase in interleukin-10 and TNF-α mRNA levels. In conclusion, the nontoxic fungal hydrophobin SC3
showed tumor-suppressive activity possibly via immunomodulation and may be of benefit as adjuvant in combination
with chemotherapy and radiation.
Keywords SC3 . Hydrophobin . Fungus . Tumor
suppression . Immunomodulation . Cytokines
Introduction