I am gratitude to KKU staffs at IN BIOMEDICAL SCIENCES
GRADUATE SCHOOL KHON KAEN UNIVERSITY
for sacrificing their time on this program. Especially her supervisor, Assistant Professor Dr. Kornkanok Ingkaninan for her invaluable guidance, supervision and constant inspiration throughout the study. Also, she is greatly thankful to Prof. dr. Hubertus Irth, Vrije Universiteit, Amsterdam the Netherlands for his kindness for offering her a good opportunity to know how research work is done.