RBC cytoplasm consists of 95% hemoglobin. The erythrocyte membrane includes a lipid bilayer composed of 10% carbohydrate, 40% lipid and 50% protein [7].Membrane-associated cytoskeletal proteins include band 3 (anion exchanger protein), spectrin, glycophorin C, ankyrin, and
protein band 4.1. These proteins have key roles in control of cell shape, attachment to substrates and other cells, and formation of specialized membrane domains [8]. All of the lipids in the mature erythrocyte consist of cholesterol and phospholipids in 1:1.2 molar ratios, which
are found in the membrane bilayer. Approximately one-half of the fatty acids in the membrane are unsaturated [7]. Interestingly, outer surface lipids exchange freely with the plasma lipid compartment [9] In addition, the structure of the lipid bilayer is critical to the cytoskeleta
network organization within the RBC [8].