•Studies investigating hyper-arousal in primary insomnia including studies of chronic insomnia employing various methodologies to assess autonomic, neuroendocrine and immunological, electrophysiological, neuropsychological and neuroimaging endpoints
•Studies investigating the relationship of subjective to objective sleep measures, aiming to better characterize sleep state misperception and drivers of subjective efficacy of insomnia medications
•Studies investigating the effects of (BZRA) insomnia drugs on resting state brain networks and on the response to cognitive tasks using fMRI
•Studies investigating the effects of current insomnia medications on the following areas: