Inhibition of electron transport ch

Inhibition of electron transport chain I by MPP+, a toxic metabolite of MPTP, leads to the leaking of electrons, which may generate the production of ROS (5–7 times more) by react- ing with excessively available O2. Previous studies from our lab, clearly indicated that the administration of MPTP has been reported to enhance the levels of TBARS, a marker of lipid peroxidation processes and activities of SOD and catalase and diminished the levels of GSH and activity of GPx [25], which may reflect an adaptive response to oxidative stress. Lycopene is described as the most effective antioxidants in the carotenoid family and exhibits 10-fold, 47-fold and 100-fold more effec- tive in quenching singlet oxygen than