In conclusion, the chemical conjugates of CS-CA nanogel with different graft ratio and molecular weight of CS were successfully synthesized using coupling reaction (self-aggregation), of water soluble CS and CA. The mean diameter of the gel nanoparticles produced was below 100 nm with uniform size distribution and spherical shape. The CS-CA nanogel system was then used as a promising encapsulating material for C. cyminum essential oils due to the slow-release characteristic of the nanogel. Finally, the MIC analyses revealed the increased antifungal activity of CS-CA