This work was financially supported by Annual Thai Government Statement of Expenditure (2006e2007) and Graduate School, Prince of Songkla University. Special gratitude is granted to the passing Assoc. Prof. KidchakanSupamataya, Ph.D (Aquatic Animal
Diseases) from the Department of Aquatic Science, Faculty of Natural Resources, Prince of Songkla University for his valuable guidance and support throughout the in vivo experiments.