Epitope-specific CD8+ T cells confer protection against infection with RA59-gfp/gp33.We wanted to determine the ability of the CD8+ T-cell response against a single epitope to protect mice from MHV replication and disease. The strategy was to carry out immunization with an rLm expressing gp33 (rLm-gp33) followed by challenge with RA59-gfp/gp33.