3.1 Distribution
Steady-state concentrations of clevidipine in arterial and
venous blood were rapidly attained within »2 and »10 minutes,
in healthy volunteers receiving intravenous clevidipine 0.91 or
3.2mg/kg/min over 20 minutes or 24 hours, and were »2-fold
higher in arterial than venous blood during 24-hour infusions.[6] Such differences between arterial and venous clevidipine concentrations may be due to loss of the drug during its
passage through the microcirculation.[6]