Loss is the fact of no longer having something or of having less of it than before
The loss of income for the government is significant
A loss is the disadvantage you suffer when a valuable and useful person or thing leaves or is taken away
Pain is the unhappiness that you feel when something upset happens
his eyes were filled with pain
If someone relieves you of something, they take it away from you
A porter relieved her of the three large suitcases