There is increasing public health concern over the risk of inadvertent transmission of swine HEV from pig organs to human recipients during xenotransplantation (21). The data presented here indicated that pigs infected with HEV had microscopic evidence of liver damage. Therefore, pig livers or cells from the livers of HEV-infected pigs used in xenotransplantation may represent a risk for transmission of HEV from pigs to human xenograft recipients. Adequate screening of xenograft donor pigs for HEV infection is therefore recommended for xenotransplantation with pig organs.