Different analytical methods have been reported
in the scientific literature for the determination
of diclofenac in plasma, urine, synovial
fluid and pharmaceutical preparations, mainly involving
spectrophotometry:colorimetry [2–9],
chromatography [10–21] and selected ion monitoring
[22]. As part of a program devoted to the
development of simple methods for quality control
in pharmaceuticals preparations [23,24], we
report on the possibility of quantitating diclofenac
in both tablets and ointments using spectrofluorometry.
This method is rapid, selective
and sensitive, and no interference from excipients
or other drugs accompanying diclofenac in the
studied commercial formulations has been observed.
This is especially important in the case of
cianocobalamine, which has been reported to be
fluorescent [25].