Hospital acquired infection is showing rising trend mainly because
of increasing use of invasive procedures4. Among iatrogenic procedures,
Endotracheal (ET) tube has been recognized as a major
threat for developing Ventilator associated Pneumonia (VAP).
Colonization of the respiratory tract is very common in intubated
patients requiring intensive care and in most instances leads to the
increase chances of infection5. Intubation with mechanical ventilation
increases the risk of pneumonia 6 to 20 folds more among
patients and is associated with crude mortality rates of 20% to
40%6,7. Among these infections, infections caused by gram-negative
bacteria have features that are of particular concern. These
organisms are highly efficient at up-regulating or acquiring genes
that code for mechanisms of antibiotic drug resistance, especially
in the presence of antibiotic selection pressure. Furthermore, they
have available to them a plethora of resistance mechanisms, often
using multiple mechanisms against the same antibiotic or using a
single mechanism to affect multiple drugs. These resistant strain
colonize the ET tube which is main threat for ventilator associated
Pneumonia in patient by prolong use of ET tube8.