Another example comes from the retrospective analysis of the use of a vaccine against B. microplus in Cuba. Its introduction was accompanied by a change in approach to the disease: the objective was no longer the total eradication of ticks; treatment was conducted only when the number of adult ticks per animal exceeded a low threshold. The result was an 87% reduction in acaricide treatments and an 82% reduction in the national consumption of acaricides, accompanied by an overall reduction in the incidence of clinical babesiosis. The large number of cattle involved more than half a million “ gave confidence in the results (59). The long-term impact on drug resistance is suggested by work in Australia, where a statistical analysis of factors associated with acaricide resistance identified the frequency of treatment as a major factor. The integrated use of a vaccine, plus restricted drug treatment as needed, should postpone the emergence of resistance (23).