In vitro assays have proven that macrophages are able to lyse or phagocytize amoebae [5], but despite the microbicidal mechanisms of macrophages to control the infection, such as the secretion of chemokines and cytokines, the Acanthamoeba produces peptidases that degrade these
substances, also, it could lyse or induce the macrophages to apoptosis, especially when the parasites are not sensitized