At diagnosis, about a quarter of people with NHL have lymphoma that started in an organ or area of the body outside the lymphatic system. This is called extranodal lymphoma. In this case, your doctor will write the letter E after the stage number. Your doctor or nurse can explain more about the staging for extranodal lymphoma.
If you have lymphoma in your spleen, your doctor will write the letter S after the stage.
Below is a simplified version of the staging system.