Hydrogels, three-dimensional cross-linked hydrophilic polymer networks, represent an important class of biomaterials because of their rubbery nature similar to soft tissues, their easy control of oxygen, nutrients, and other bioactive molecules, and their excellent biocompatibility. Hydrogels also are needed for their excellent biocompatibility for use in these applications. For these reasons, many functional hydrogels have been prepared from natural polymers such as polysaccharides and proteins and from approved synthetic polymers,particularly the hydrogels containing Ag nanoparticles that actively kill bacteria. More recently, a variety of silver-based products have been commercialized varying from wound dressings to vascular and urinary catheters. Antibacterial hydrogels can be used to directly treat accessible wounds to prevent or kill existing infection. These hydrogels can be used to deliver small molecule antibiotics, or the material itself can be designed to be the antibacterial agent, circumventing the need to encapsulate therapeutic.Traditionally, Ag nanoparticles in hybrid hydrogels were obtained by the reduction procedures involving addition of toxic reducing agents such as sodium borohydride