Western blot analysis provided the underlying
molecular mechanism, showing that TDB reduced such cell
migration and invasion by decreasing migration-regulating
proteins, including integrins av, a4, b1, b3 and b5, as well
as downstream signaling proteins, such as activated focal
adhesion kinase (pFAK), activated Ras-related C3 botulinum
toxin substrate 1 (Rac1-GTP) and cell division control
protein 42 (Cdc42).
Western blot analysis provided the underlyingmolecular mechanism, showing that TDB reduced such cellmigration and invasion by decreasing migration-regulatingproteins, including integrins av, a4, b1, b3 and b5, as wellas downstream signaling proteins, such as activated focaladhesion kinase (pFAK), activated Ras-related C3 botulinumtoxin substrate 1 (Rac1-GTP) and cell division controlprotein 42 (Cdc42).
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