Physical properties of cylindrical pellets prepared with different concentra-tions of polyvinyl alcohol (PVA) binder and DE filler (binder:filler, 5:4, w:w) at 1 kgor 3 kg of compression. (A) Force needed to crush pellets: pellets made with 1 kgcompression were crushed with top force (diamond) and side force (square) andpellets made with 3 kg compression were crushed with top force (triangle) and sideforce (×) (n = 10 for each PVA concentration, compression class, and force aspect). (B)Dissolution period for pellets made with 1 kg force (×) and 3 kg force (square) (n = 10for each concentration and compression class). Error bars for (A) and (B) representstandard error.,