The prevalence of P. aeruginosa isolation from dogs without
clinically apparent extraocular disease in this study was
comparable to previous reports in which P. aeruginosa was a
consistent, but relatively infrequent, inhabitant of the canine
extraocular microflora and was isolated from 1% to 14% of
eyes.44–50 The relative importance of conjunctival versus environmental
sources of P. aeruginosa during initiation of canine
ocular infections is unknown, but the similar prevalence
of invasive and cytotoxic strains among extraocular microflora
and infection isolates suggests that the conjunctival flora may
be an important bacterial reservoir and both phenotypes are
capable of inducing opportunistic ocular infection during appropriate
circumstances. The consistent presence of P. aeruginosa
in the normal conjunctival microflora of dogs contrasts
with humans where P. aeruginosa is most often reported to be
a rare and sporadic isolate in the absence of predisposing
extraocular disease.51–53 It is partially on the basis of these
reports that, in humans, P. aeruginosa ocular infections are
frequently believed to originate from environmental bacterial
sources.54–56 In disagreement with most studies of the human
extraocular microflora; however, sporadic large human conjunctival
microflora surveys have isolated P. aeruginosa from
5.8% to 6.7% of eyes; a prevalence similar to that reported for
dogs.57,58 Among individuals or populations where P. aeruginosa
is present in the extraocular microflora, the importance
of this endogenous source of bacteria in the pathogenesis of
ocular infections and the predisposition toward infection resultant
from its presence is currently unknown.
The prevalence of P. aeruginosa isolation from dogs withoutclinically apparent extraocular disease in this study wascomparable to previous reports in which P. aeruginosa was aconsistent, but relatively infrequent, inhabitant of the canineextraocular microflora and was isolated from 1% to 14% ofeyes.44–50 The relative importance of conjunctival versus environmentalsources of P. aeruginosa during initiation of canineocular infections is unknown, but the similar prevalenceof invasive and cytotoxic strains among extraocular microfloraand infection isolates suggests that the conjunctival flora maybe an important bacterial reservoir and both phenotypes arecapable of inducing opportunistic ocular infection during appropriatecircumstances. The consistent presence of P. aeruginosain the normal conjunctival microflora of dogs contrastswith humans where P. aeruginosa is most often reported to bea rare and sporadic isolate in the absence of predisposingextraocular disease.51–53 It is partially on the basis of thesereports that, in humans, P. aeruginosa ocular infections arefrequently believed to originate from environmental bacterialsources.54–56 In disagreement with most studies of the humanextraocular microflora; however, sporadic large human conjunctivalmicroflora surveys have isolated P. aeruginosa from5.8% to 6.7% of eyes; a prevalence similar to that reported fordogs.57,58 Among individuals or populations where P. aeruginosais present in the extraocular microflora, the importanceof this endogenous source of bacteria in the pathogenesis ofocular infections and the predisposition toward infection resultantfrom its presence is currently unknown.
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