- Donor organ management should include frequent assessment of arterial PO2, with ideal ranges greater than 300 during 100% FiO2 “challenges” For donors who have lower or deteriorating arterial oxygen concentration, alveolar recruitment measures can include increasing positive end-expiratory pressure (PEEP) or using ventilator strategies such as inverse ratio or airway pressure release ventilation (APRV) modes. Prone positioning also can be considered. Use of an opioid inverse agonist, for example, naloxone, can be considered to ameliorate neurogenic pulmonary edema. After successful recruitment with such measures, reassessment of arterial PO2 should be considered to determine whether acceptable oxygenation can be maintained,