A benign lymphoepithelial lesion (BLEL) is an
idiopathic inflammation of the parotid gland, characterized
by hyperplasia, lymphocyte infiltration and the formation
of epimyoepithelial islands, as well as atrophy of the gland
parenchyma. Common treatment methods include immunosuppression
and glucocorticoid therapies, in addition to surgical
dissections. Cytokine‑induced killer (CIK) cells sensitized to
specific antigens by dendritic cells (DCs) are used in DC‑CIK
biotherapy. The present study reports the case of a 22‑year‑old
female suffering from a postoperative recurrent BLEL on the
left parotid gland, which was gradually increasing. Following
initial unsuccessful conservative treatment attempts, a 10‑day
course of DC‑CIK therapy was initiated, after which the lesion
in the gland area was reduced in size and local infection and
skin ulcerations were improved. DC‑CIK biotherapy was
continued for three months (four sessions of 10‑day treatments
with a 10‑day break in between) until the lesion disappeared
and the skin ulceration was healed. Computerized tomography
scans of the parotid gland revealed complete remission of
the primary lesion and recovery of the bone destruction. The
patient was discharged and remained stable with no sign of
recurrence during a 10‑month follow‑up period. In the present
case report, a successful DC‑CIK adoptive cellular immunotherapy
treatment for a BLEL was described for the first time