sinusitis (inflammation but not allergy), SP-A was more
prevalent than in pathogen-free animals.3
The SP-A protein levels were significantly reduced compared
with controls in PAR patients. A possible explanation is
that absence of significant SP-A gene up-regulation and
depletion of SP-A protein reserves in the presence of atrophic
changes of the submucosal glands and mucosa. This is in
agreement with the results obtained by Sayed et al, who had
demonstrated a significant decrease in phospholipid and
surfactant concentrations in the cases with PAR compared
with normal cases.13