Statistical Analysis. Data were expressed as mean ± SEM. Statistical analyses were performed with Prism 4.03 software (GraphPad, San Diego, CA). Correlation coefficients were calculated with Pearson correlation analyses. Means between two groups were compared with two-tailed, unpaired Student's t tests; comparisons of means from multiple groups with one control were analyzed with one-way ANOVA and Dunnet's post hoc test.