In this study we reported the role of the nanoencapsulation in the protective effects of RBO against UVB radiation-induced skin injury in mice. Furthermore, the in vivo results support the remarkable advantages of RBO encapsulation in LNC, showing that this strategy is essential to improve the antioxidant and anti-edematogenic effects after cutaneous administration, as hydrogels. These results indicate that this strategy may be a suitable tool for the development of skin product containing vegetable oils intended to reduce skin