The typical disease presentation usually follows a specific course of events that has been well recognized and continues to this day.[8] Nephrotic syndrome that occurs in younger children is generally more severe and virulent. Patients complain of edema that has progressed over the preceding few weeks, often triggered by an upper respiratory infection that preceded the onset of edema by 2-3 days.[8] Periorbital swelling and dermal irritation are often misdiagnosed as an allergic reaction.[8] The edema eventually becomes more generalized, with ascites and rapid weight gain. The course and extent of disease is related to the amount of protein excreted in the urine.[8-10] The loss of protein in the urine results in hypoalbuminemia, serum albumin concentration below 2.5 g/dl, and subsequent fluid retention.[8, 10] Microscopic hematuria, transient azotemia, elevated erythrocyte sedimentation rate, and hyperlipidemia may also be evident.[8] Patients with progressive and virulent types of nephrotic syndrome may also develop hypertension, resulting in increased renal injury.