Summary
Ethanolic extract of Pluchea indica leaf (PIL) was used to
investigate its anti-inflammatory and antinociceptive
activities by using carrageenan – induced oedema model
and acetic acid induced writhing test. PIL exhibited
significant and dose-dependent anti-inflammatory activity
at a dose of 300 mg/kg when administered orally. It is also
demonstrated that the i.p administration of PIL at a dose of
10, 30, 100 and 300 mg/kg produced significant inhibition
of abdominal constriction induced with 0.6% (v/v) acetic
acid in dose dependent manner. These results indicate that
PIL exhibits significant anti-inflammatory and
antinociceptive effects.