Although
the limits of detection (LoD) of parasitaemia by microscopy
(100 parasites/μL or higher depending on technical
skills) [16,17] and RDT (50–400 parasites/μL) [18] may be
well below the estimated parasite density threshold (3,500
parasites/μL) for initiation of febrile episodes [19], many
clinicians in areas of high malaria endemicity are compelled
to heuristically prescribe anti-malarials on the basis
of clinical symptoms alone