The oral median LD50 of the extract was estimated to be
≥2000 mg/kg in mice. There were no remarkable behavioral
changes in the extract administered mice (reaction to food
supply, contact and noise), though activity was reduced in some
of the extract administered groups within the first 4 h. And no
mortality occurred within the observation period of 14 days.
However, behavioral signs of toxicity were observed in mice
given 2000 mg stem extract/kg body weight which include; paw
licking, salivation, stretching and reduced activity. There was
however no mortality at all the dose levels used. And the oral
median LD50 was estimated to be ≥2000 mg extract/kg body
weight [Tables 3 and 4].