The major phenolic compound analyzed in the cranberry, which is berries are a rich source of phenolic phytochemicals, is quercetin. These phenolics have been proposed to have beneficial effects on health as antioxidants and anticarcinogens. Berries have potential as good dietary sources of quercetin. A dose of pharmacokinetic trial was conducted in 10 healthy adults ≥ 50 y to evaluate the acute (24-h) absorption and excretion of flavonoids and phenolic acid from a low-calorie cranberry 54% juice. Inter-individual variability was observed in the maximum concentration and time to maximum concentration of many of these compounds in both plasma and urine. After cranberry juice consumption, plasma total antioxidant capacity assessed using oxygen radical absorbance capacity and total antioxidant performance assays correlated with individual metabolites.