2.4. Statistical methods
Cox Regression analysis was used to calculate the multivariable
adjusted hazard ratios in different levels of chocolate intake. In
order to account for changes over time in the predictor, chocolate
consumption, the chocolate consumption values at exam 1 were
updated at exam with available chocolate consumption values. A
time-dependent covariates analysis was used to achieve the
updating. A sensitivity analyses was conducted using only the
actual chocolate intake at exam 1 as predictor - without updating
at exam 3.