Changes of Inflammatory Cytokines
The mean levels of IL-1α, IL-1β, and TNF-α in all groups at day 7 were shown in Figure 1. The IL-1α level in the APAP group was significantly higher than that of the control group (p < 0.05) (Figure 1(a)). However, there was no significant difference in IL-1β and TNF-α between the control and the APAP group (Figures 1(b) and 1(c)). The level of IL-1α, IL-1β, and TNF-α in the APAP group was significantly higher compared to the treated groups (p < 0.05) which indicated that P. major treatment significantly reduced the proinflammatory cytokines. The mean levels of IL-6 and IL-10 in all groups were shown in Figure 2. The levels of IL-6 and IL-10 in all groups showed no significant difference (p > 0.05).