The involvement of oxidative stress has been
reported as a mechanism by which complications
develops in diabetes mellitus [11–16]. Especially,
lipid peroxide is considered to be a factor for the
progression of diabetic nephropathy [17]. Probucol
was developed as a cholesterol-lowering agent and is
found to have antioxidant effect [18–20]. Probucol has
been reported to reduce lipid peroxide [21]. We
hypothesized that probucol suppresses the progression
of diabetic nephropathy through its antioxidant as well
as cholesterol-lowering effects. In this study, we
administrated probucol to patients with diabetic
nephropathy, and examined the effect of probucol
on the progression of diabetic nephropathy.